解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::In vitro cultured blood cells for transfusion purposes provide a safe alternative to donor blood, particularly for patients who require recurrent transfusions, and can be used as carriers of therapeutic molecules. In vitro derivation of hematopoietic cell types from human-induced pluripotent stem cells (iPSCs) allows ...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.13599
更新日期:2019-12-01 00:00:00
abstract::Diapause is an important overwintering strategy enabling Locusta migratoria to survive under stressed conditions. We identified a novel dual-specificity kinase gene that is differentially expressed between long and short day-treated L. migratoria. To determine its function on photoperiodic diapause induction, we clone...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13544
更新日期:2019-11-01 00:00:00
abstract::Physiological amyloid aggregation occurs within the nuclei of stress-treated cells. These structures, termed Amyloid bodies (A-bodies), assemble through the rapid accumulation of proteins into dense membrane-less organelles, which possess the same biophysical properties as plaques observed in many amyloid-based diseas...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13597
更新日期:2019-11-01 00:00:00
abstract::In addition to the classical functions of the Golgi in membrane transport and glycosylation, the Golgi apparatus of mammalian cells is now recognised to contribute to the regulation of a range of cellular processes, including mitosis, DNA repair, stress responses, autophagy, apoptosis and inflammation. These processes...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.13567
更新日期:2019-09-01 00:00:00
abstract::Organelles have been studied traditionally as single units, but a novel concept is now emerging: each organelle has distinct functional zones that regulate specific functions. The Golgi apparatus seems to have various zones, including zones for: glycosylphosphatidylinositol-anchored proteins; proteoglycan, mucin and l...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.13554
更新日期:2019-09-01 00:00:00
abstract::Chemotherapy is a major anticancer therapeutic modality, however, multidrug resistance (MDR) is frequently observed and hinders treatment efficacy. Here, we investigated the role and potential mechanism of the long noncoding RNA (lncRNA) FENDRR in adriamycin resistance of chronic myeloid leukaemia (CML) cells. FENDRR ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13480
更新日期:2019-08-01 00:00:00
abstract::Connivance of cellular factors during virus-host cell membrane fusion is poorly understood. We have recently shown that cellular villin plays an important role during membrane fusion of reconstituted Sendai virosomes with hepatocytes. Here, we employed villin-null Chinese Hamster Ovary (CHO) cells, where villin expres...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13477
更新日期:2019-08-01 00:00:00
abstract::With the aging of population, neurological disorders, and especially disorders involving defects in protein conformation (also known as proteopathies) pose a serious socio-economic problem. So far there is no effective treatment for most proteopathies, including Parkinson's disease (PD). The mechanism underlying PD pa...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.13464
更新日期:2019-07-01 00:00:00
abstract::When a cell divides prior to completion of DNA replication, serious DNA damage may occur. Thus, in addition to accuracy, the processivity of the replication forks is important. DNA synthesis at replication forks should be completed in time, and forks overcome aberrant structures on the template DNA, including damaged ...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.13481
更新日期:2019-07-01 00:00:00
abstract::Apolipoprotein E (APOE) genotype determines Alzheimer's disease (AD) susceptibility, with the APOE ε4 allele being an established risk factor for late-onset AD. The ApoE lipidation status has been reported to impact amyloid-beta (Aβ) peptide metabolism. The details of how lipidation affects ApoE behavior remain to be ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13428
更新日期:2019-06-01 00:00:00
abstract::RNA molecules have been found to play important roles in DNA double-strand break (DSB) repair, but the exact underlying mechanism remains unclear. Here, we aimed to clarify the function of RNase L, an important ribonuclease in the immune system of vertebrates, in DSB repair. Knockdown of RNase L reduces cell survival ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13426
更新日期:2019-06-01 00:00:00
abstract::Motile flagella are crucial for human fertility and embryonic development. The distal tip of the flagellum is where growth and intra-flagellar transport are coordinated. In most model organisms, but not all, the distal tip includes a 'singlet region', where axonemal doublet microtubules (dMT) terminate and only comple...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13379
更新日期:2019-05-01 00:00:00
abstract::In the unfolded protein response (UPR), Ire1 activates Hac1 to coordinate the transcription of hundreds of genes to mitigate ER stress. Recent work in Caenorhabditis elegans suggests that oxidative stress inhibits this canonical Ire1 signalling pathway, activating instead an antioxidant stress response. We sought to d...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13389
更新日期:2019-05-01 00:00:00
abstract::CD133 is a widely used cell surface marker of cancer stem cells that plays an important role in tumor initiation and metastasis. Increasing evidence shows that CD133 is secreted to the extracellular space. However, the underlying mechanisms of CD133 secretion remain largely unknown. In this study, we report that secre...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13358
更新日期:2019-04-01 00:00:00
abstract::Differences in the metabolism of cancer cells or cancer stem cells (CSCs) as compared to normal cells have provided avenues to safely target cancers. To discover metabolic inhibitors of CSCs, we performed alkaline phosphatase- and tumoursphere-based drug screening using induced cancer stem cell-like cells. From the sc...
journal_title:FEBS letters
pub_type: 社论
doi:10.1002/1873-3468.13361
更新日期:2019-04-01 00:00:00
abstract::Early results showed the emanation of chromatin fibers from mitotic chromosomes and nuclei swollen with water. In contrast, under metaphase ionic conditions, it was found that chromatin from mitotic chromosomes is planar and forms multilayered plates. Here, we show that in buffers containing interphase cation concentr...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13370
更新日期:2019-04-01 00:00:00
abstract::Until cytoplasmic recapping was discovered, decapping was thought to irreversibly destine an mRNA to degradation. Contradicting this idea, we readily observe mRNAs targeted by cytoplasmic capping in uncapped, yet stable forms. 5' rapid amplification of cDNA ends (RACE) shows that nearly all uncapped ends correspond to...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13349
更新日期:2019-04-01 00:00:00
abstract::Read-through or mutations of a stop codon resulting in translation of the 3'-UTR produce potentially toxic C-terminally extended proteins. However, quality control mechanisms for such proteins are poorly understood in mammalian cells. Here, a comprehensive analysis of the 3'-UTRs of genes associated with hereditary di...
journal_title:FEBS letters
pub_type: 社论
doi:10.1002/1873-3468.13362
更新日期:2019-04-01 00:00:00
abstract::Ferric reductase B (FerB) is a flavin mononucleotide (FMN)-containing NAD(P)H:acceptor oxidoreductase structurally close to the Gluconacetobacter hansenii chromate reductase (ChrR). The crystal structure of ChrR was previously determined with a chloride bound proximal to FMN in the vicinity of Arg101, and the authors ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13359
更新日期:2019-04-01 00:00:00
abstract::There is a paucity of information on the unique components that pathogens use to form respiratory chains. It is not known why mycobacteria encode multiple succinate dehydrogenases (SDHs) to perform menaquinone-linked succinate oxidation, a thermodynamically unfavorable reaction (ΔG° = +21 kJ·mol-1 ). In other bacteria...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13330
更新日期:2019-03-01 00:00:00
abstract::Bacterial RNA polymerase (RNAP) serves as a primase during replication of single-stranded plasmids and filamentous phages. Primer RNA (prRNA) synthesis from the origin regions of these replicons depends on the σ factor that normally participates in promoter recognition. However, it was proposed that σ may not be requi...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13312
更新日期:2019-02-01 00:00:00
abstract::Cytoplasmic dynein, a microtubule-based motor protein, is responsible for many cellular functions ranging from cargo transport to cell division. The various functions are carried out by a single isoform of cytoplasmic dynein, thus requiring different forms of motor regulation. A possible pathway to regulate motor func...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13319
更新日期:2019-02-01 00:00:00
abstract::Mesothelial cells, which cover the surface of visceral organs and serous cavities in mammals, play a crucial role in preventing adhesion. We previously reported that primary mesothelial progenitor cells (MPCs) can not only prevent postoperative adhesion but also promote liver regeneration after hepatectomy. Induced pl...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13325
更新日期:2019-02-01 00:00:00
abstract::G2/M checkpoints ensure the proper timing of cell mitosis. We previously reported that p38 mitogen-activated protein kinase (MAPK) activation is essential for stress-induced G2 arrest in the U-2OS osteosarcoma cell line, but the molecular mechanism was obscure. Here, using the T7 phage display system, we find p38 dire...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13272
更新日期:2018-12-01 00:00:00
abstract::In plant organelle genomes, homeologous recombination between heteroallelic positions of repetitive sequences is increased by dysfunction of the gene encoding MutS homolog 1 (MSH1), a plant organelle-specific homolog of bacterial mismatch-binding protein MutS1. The C-terminal region of plant MSH1 contains the GIY-YIG ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13279
更新日期:2018-12-01 00:00:00
abstract::Ribonucleoprotein complexes, which contain mRNAs and their regulator proteins, carry out post-transcriptional control of gene expression. The function of many RNA-binding proteins depends on their association with cofactors. Here, we use a genomic approach to identify transcripts associated with DLC-1, a protein previ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13259
更新日期:2018-11-01 00:00:00
abstract::The timely and reliable processing of auditory and vestibular information within the inner ear requires highly sophisticated sensory transduction pathways. On a cellular level, these demands are met by hair cells, which respond to sound waves - or alterations in body positioning - by releasing glutamate-filled synapti...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.13258
更新日期:2018-11-01 00:00:00
abstract::In presynaptic nerve terminals, synaptic vesicles are recycled locally via an evolutionarily conserved process that ensures maintenance of neurotransmission as well as structural integrity of synapses. Temperature is a key environmental factor that impacts critical steps involved in fusion, endocytosis and transport i...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.13268
更新日期:2018-11-01 00:00:00
abstract::To date the only tRNAs containing nucleosides modified with a selenium (5-carboxymethylaminomethyl-2-selenouridine and 5-methylaminomethyl-2-selenouridine) have been found in bacteria. By using tRNA anticodon-stem-loop fragments containing S2U, Se2U, or geS2U, we found that in vitro tRNA 2-selenouridine synthase (SelU...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13124
更新日期:2018-07-01 00:00:00
abstract::In this work, we investigated electron transport around the photosynthetic pigment-protein complex of Photosystem I (PS I) mediated by external high-potential electron carrier 2,3-dichloro-1,4-naphtoquinone (Cl2 NQ) and ascorbate. It has been demonstrated that the oxidized species of Cl2 NQ and ascorbate serve as inte...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13154
更新日期:2018-07-01 00:00:00
abstract::α-Glucosidase hydrolyzes α-glucosides and transfers α-glucosyl residues to an acceptor through transglucosylation. In this study, GH13_31 α-glucosidase BspAG13_31A with high transglucosylation activity is reported in Bacillus sp. AHU2216 and biochemically and structurally characterized. This enzyme is specific to α-(1...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13126
更新日期:2018-07-01 00:00:00
abstract::The chromatin structure in one-cell-stage mouse embryos is extremely loose and becomes tighter at the two-cell stage. As linker histones are involved in higher-order chromatin structure, we examined the involvement of the linker histone variant H1foo in the change of chromatin looseness between the one- and two-cell s...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13175
更新日期:2018-07-01 00:00:00
abstract::Duchenne muscular dystrophy (DMD) is a fatal disorder caused by absence of functional dystrophin protein. Compensation in dystrophin-deficient (mdx) mice may be achieved by overexpression of its fetal paralogue, utrophin. Strategies to increase utrophin levels by stimulating promoter activity using small compounds are...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.13099
更新日期:2018-06-01 00:00:00
abstract::Mice are widely used for exploring obesity physiology and treatment. However, thermal biology is different between small and large mammals. In this Review, we discuss how the effect of environmental temperature must be understood to ensure applicability of mouse experiments to human obesity. At ambient environmental t...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.13070
更新日期:2018-06-01 00:00:00
abstract::The human gut microbiome refers to a highly diverse microbial ecosystem, which has a symbiotic relationship with the host. Molecular hydrogen (H2 ) and carbon dioxide (CO2 ) are generated by fermentative metabolism in anaerobic ecosystems. H2 generation and oxidation coupled to CO2 reduction to methane or acetate help...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.13064
更新日期:2018-06-01 00:00:00
abstract::DNA methylation has a profound impact on the regulation of gene expression in normal cell development, and aberrant methylation has been recognized as a key factor in the pathogenesis of human diseases such as cancer. The discovery of modified nucleobases arising from 5-methylcytosine (5mC) through consecutive oxidati...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.13058
更新日期:2018-06-01 00:00:00
abstract::The DNA mismatch repair endonuclease MutL consists of N-terminal ATPase and C-terminal endonuclease domains. The endonuclease domain binds zinc ion, although the ion seems not to function as a catalytic metal ion. Here, we solved the crystal structures of the Aquifex aeolicus MutL (aqMutL) endonuclease domain complexe...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.13050
更新日期:2018-05-01 00:00:00
abstract::α-Synuclein (αSyn) is a key player in the pathogenesis of Parkinson's disease and other synucleinopathies. Here, we report the existence of a novel soluble α-helical conformer of αSyn, obtained through transient interaction with lipid interfaces, and propose dynamic oligomerization as the mechanism underlying its stab...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13047
更新日期:2018-05-01 00:00:00
abstract::Gemin5 acts as a U1 small nuclear RNA (snRNA)-binding protein in U1 small nuclear ribonucleic protein (snRNP) biogenesis. Here, we report a role for Gemin5 in unassembled U1 snRNP disposal under survival of motor neuron (SMN) protein-deficient conditions. We demonstrate that non-Sm protein-associated U1 snRNA and U1A ...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.13031
更新日期:2018-04-01 00:00:00
abstract::As a SNARE binding protein, tomosyn has been reported to negatively regulate synaptic exocytosis via arresting syntaxin-1 and SNAP-25 into a nonfusogenic product that precludes synaptobrevin-2 entry, raising the question how the assembly of the SNARE complex is achieved. Here, we have investigated new functions of tom...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.13018
更新日期:2018-04-01 00:00:00